Inflammatory Reprogramming by Ageing and Microbiome - Targets for Treatment of Cardiovascular Disease

IN-CONTROL II will seek to i. unravel the mechanisms driving 'trained immunity" in patients, taking into account the impact of senescence, age, gender and obesity, ii. elucidate the interactions between microbiome-derived signals and (immune) senescence in the etiology of obesity-related cardio-metabolic diseases, and iii. to pursue and to identify new therapeutic targets and to design novel pharmacological and microbiome-based therapies to counteract inappropriate induction of trained immunity and inflammatory processes in cardiovascular disease.

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Veld	Waarde
Titel	Inflammatory Reprogramming by Ageing and Microbiome - Targets for Treatment of Cardiovascular Disease
Omschrijving	IN-CONTROL II will seek to i. unravel the mechanisms driving 'trained immunity" in patients, taking into account the impact of senescence, age, gender and obesity, ii. elucidate the interactions between microbiome-derived signals and (immune) senescence in the etiology of obesity-related cardio-metabolic diseases, and iii. to pursue and to identify new therapeutic targets and to design novel pharmacological and microbiome-based therapies to counteract inappropriate induction of trained immunity and inflammatory processes in cardiovascular disease.
Keywords	Atherosclerosis Biological samples Birth cohort Cohort DNA Disease specific Feaces Female Genomics IN-CONTROL II Imaging data Male Metabolomics Non-Human Obesity Peripheral blood cells Physiological... Plasma Population-based Proteomics RNA Serum Tissue Transcriptomics cDNA mRNA cryo preserved paraffin preserved
Contact points	Contact point 1 URI Naam DCVA Name (translations) Email info@dcvalliance.nl Identifier URL https://www.dcvalliance.nl/
Publisher	Publisher 1 URI Naam Dutch Cardiovascular Alliance (DCVA) Name (translations) Email info@dcvalliance.nl URL https://www.dcvalliance.nl/ Type Publisher note Publisher type Identifier DCVA
Creator	Creator 1 URI Naam Dutch Cardiovascular Alliance (DCVA) Name (translations) Email info@dcvalliance.nl URL https://www.dcvalliance.nl/ Type Publisher note Publisher type Identifier DCVA
Landing page
Release date	2019-05-01T00:00:00+00:00
Modification date
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Version notes
Identifier	DCVA-005
Frequency
Provenance
Type
Temporal coverage	Temporal coverage 1 Start 2019-05-01T00:00:00+00:00 End 2024-04-30T00:00:00+00:00
Temporal resolution
Spatial coverage	Spatial coverage 1 URI http://publications.europa.eu/resource/authority/country/NLD Label Geometry Bounding Box Centroid
Spatial resolution in meters
Access rights	http://publications.europa.eu/resource/authority/access-right/RESTRICTED
Other identifier
Theme	http://publications.europa.eu/resource/authority/data-theme/HEAL
Taal	http://id.loc.gov/vocabulary/iso639-1/en
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Applicable legislation	http://data.europa.eu/eli/reg/2025/327/oj
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Minimum typical age	18
Maximum typical age	90
Number of records
Number of records for unique individuals.	1802
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Trusted Data Holder
Population coverage	collection type: Birth cohort,Cohort,Disease specific,Non-Human,Population-based \| disease: Atherosclerosis,Obesity \| data categories: Biological samples,Imaging data,Physiological/Biochemical measurements \| materials: cDNA / mRNA,DNA,Feaces,Peripheral blood cells,Plasma,RNA,Serum,Tissue, cryo preserved,Tissue, paraffin preserved \| omics: Genomics,Metabolomics,Proteomics,Transcriptomics \| imaging: Y \| sex: Female,Male
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Qualified attribution	Attribution 1 Agent Agent 1 URI Naam Dutch Cardiovascular Alliance (DCVA) Name (translations) Email info@dcvalliance.nl URL https://www.dcvalliance.nl/ Homepage Type Identifier DCVA Rol
Quality annotations
URI	https://fdp.heart-institute.nl/dataset/122cc950-ae28-452e-93e8-ee51bbaaac5d