127 datasets found

Pregnant women included in LLNEXT. They are followed from the third months of pregnancy until one year after delivery.

Children of pregnant women included in LLNEXT. They are followed until one year after birth.

We have established a hospital-based data-biobank, entitled OncoLifeS (Oncological Life Study: Living well as a cancer survivor) to link routinely collected clinical data with...

Lifelines NEXT (LLNEXT) is a birth cohort designed to study the effects of intrinsic and extrinsic determinants on health and disease as epidemiological research has shown there...

Neoadjuvant immune checkpoint blockade (ICB) has shown unprecedented activity in mismatch repair deficient (MMRd) colorectal cancers, but its effectiveness in MMRd endometrial...

The Lifelines-NEXT is a cohort of newborns followed up from birth up to the age of 1 year and later. The cohort includes approximately 1,500 newborns and their mothers from the...

CS Baby Biome randomized control trial aims to investigate if the timing of intrapartum antibiotics given to mother influences the infant gut microbiome composition. The study...

Primary bronchial epithelial cells derived from healthy donors and asthma patients were differentiated in Air-Liquid-Interface condition and infected with the respiratory...

Inflammatory bowel diseases (IBD), e.g. Crohn’s disease (CD) and ulcerative colitis (UC), are chronic immune-mediated inflammatory diseases. A comprehensive overview of an IBD-...

The immune response plays a pivotal role in initiating cardiac repair and remodeling in both the acute and chronic phase after ST-Elevated myocardial infarction (STEMI). To...

Bacteriophage Immunoprecipitation Sequencing (PhIP-Seq) of LLD participants. Libraries and protocol were developed in the Weizmann Institute of Science. Two different libraries...

scRNA-seq samples from healthy and asthma donors part 1.

This dataset was collected from viable bone marrow cells obtained at diagnosis from nine patients with high hyperdiploid ALL and one normal bone marrow sample. All samples were...

TransplantLines is designed as a single-center, prospective cohort study and biobank including all different types of solid organ transplant recipients as well as living organ...

This study aims to dissect gene-environment interactions on gene expression and regulation in immune cells using scRNA-seq data from 120 donors being stimulated with 3...

Gluten-free diet intervention: 11 individuals, 3 time points (T1: 1 week before intervention, T2: at the intervention; T3: 5 weeks after intervention. Fecal samples taken at...

We used machine learning models to systematically integrate large-scale multi-omics data from genomics, DNA methylation in blood, and nasal and environmental factors. We firstly...

The Dutch Microbiome Project (DMP) data includes raw data generated by shotgun metagenomic sequencing of faecal samples of 8,208 Dutch individuals, processed microbiome data...

Asthma is a chronic respiratory disease which is not curable, yet some patients experience spontaneous remission.In this study, we hypothesized that epigenetic mechanisms may be...

Celiac disease (CeD) is a common immune-mediated disease of the small intestine that is triggered by exposure to dietary gluten. While the HLA locus plays a major role in...