The EuroTARGET cohort: A European project on TArgeted therapy in renal cell cancer-GEnetic- and tumor-related biomarkers for response and toxicity

EuroTARGET is a European collaborative project designed as an observational study for which patients with mRCC were recruited prospectively in 62 centers. In total, 1,210 patients with mRCC were included. Of these, 920 received a tyrosine kinase inhibitor as first-line targeted treatment (sunitinib, sorafenib or pazopanib) and had at least 6 months of outcome assessment (median follow-up 15.3 months). Detailed clinical information (baseline and follow-up) from all patients was entered in web-based case record forms. Blood was collected for germline DNA and pharmacokinetic/pharmacodynamic analyses and, where available, fresh-frozen tumor material was collected to perform tumor DNA, RNA, kinome, and methylome analyses.

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Titel The EuroTARGET cohort: A European project on TArgeted therapy in renal cell cancer-GEnetic- and tumor-related biomarkers for response and toxicity
Omschrijving

EuroTARGET is a European collaborative project designed as an observational study for which patients with mRCC were recruited prospectively in 62 centers. In total, 1,210 patients with mRCC were included. Of these, 920 received a tyrosine kinase inhibitor as first-line targeted treatment (sunitinib, sorafenib or pazopanib) and had at least 6 months of outcome assessment (median follow-up 15.3 months). Detailed clinical information (baseline and follow-up) from all patients was entered in web-based case record forms. Blood was collected for germline DNA and pharmacokinetic/pharmacodynamic analyses and, where available, fresh-frozen tumor material was collected to perform tumor DNA, RNA, kinome, and methylome analyses.
Keywords
Contact points
Contact point 1
URI
mailto:Sander.Bervoets@radboudumc.nl
Naam
Sita Vermeulen
Name (translations)
Email
Sita.Vermeulen@radboudumc.nl
Identifier
URL
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Publisher
Publisher 1
URI
Naam
Radboudumc
Name (translations)
Email
Sander.Bervoets@radboudumc.nl
URL
https://radboudumc.nl
Type
Publisher note
Publisher type
Identifier
https://ror.org/05wg1m734
Creator
Creator 1
URI
Naam
Radboudumc
Name (translations)
Email
iqhealth@radboudumc.nl
URL
https://radboudumc.nl
Type
Publisher note
Publisher type
Identifier
https://ror.org/05wg1m734
Landing page
Release date 2024-12-30T23:00:00+00:00
Modification date
In Series
    Versie
    Version notes
    Identifier https://ega-archive.org/studies/EGAS50000000798
    Frequency http://publications.europa.eu/resource/authority/frequency/NEVER
    Provenance
    Type
    Temporal coverage
    Temporal resolution
    Spatial coverage
    Spatial resolution in meters
    Access rights http://publications.europa.eu/resource/authority/access-right/NON_PUBLIC
    Other identifier
    Theme
    1. http://publications.europa.eu/resource/authority/data-theme/HEAL
    Taal
    1. http://publications.europa.eu/resource/authority/language/ENG
    Documentation
    1. https://ega-archive.org/studies/EGAS50000000798
    Conforms to
    Is referenced by
    Distribution
    1. https://fdp.radboudumc.nl/distribution/0c0c23a2-a004-4c3b-9fdd-00701010bd1d
    Sample
    Analytics
    Applicable legislation
    1. http://data.europa.eu/eli/reg/2025/327/oj
    Has version
    Code values
    Coding system
    Purpose
    1. https://w3c.github.io/dpv/2.1/dpv/#AcademicResearch
    2. https://w3c.github.io/dpv/2.1/dpv/#ImproveHealthcare
    3. https://w3c.github.io/dpv/2.1/dpv/#ResearchAndDevelopment
    Health category
    Health theme
    Legal basis
    Minimum typical age
    Maximum typical age
    Number of records
    Number of records for unique individuals. 268
    Personal data
    Publisher note
    Publisher type
    Trusted Data Holder
    Population coverage

    Adults in Europe diagnosed with with metastatic renal cell cancer and being treated with sunitinib, sorafenib, or pazopanib.
    Retention period
    Health data access body
    Qualified relation
    Provenance activity
    Qualified attribution
    Quality annotations
    URI https://fdp.radboudumc.nl/dataset/214c68c0-40af-4c25-9237-90afe22881b6