Technology Of Protein delivery through Extracellular Vesicles to target PCSK9

High total cholesterol levels are a major cause of disease burden in both the developed and developing world as a risk factor for ischemic heart disease and stroke. Lowering cholesterol has been one of the most effective strategy to prevent major cardiovascular event. In this study, we will try to develop a new treatment for hypercholesterolemia by permanently removing PCSK9 from hepatocytes by using cell-derived vesicles.

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Titel Technology Of Protein delivery through Extracellular Vesicles to target PCSK9
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High total cholesterol levels are a major cause of disease burden in both the developed and developing world as a risk factor for ischemic heart disease and stroke. Lowering cholesterol has been one of the most effective strategy to prevent major cardiovascular event. In this study, we will try to develop a new treatment for hypercholesterolemia by permanently removing PCSK9 from hepatocytes by using cell-derived vesicles.
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Contact point 1
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DCVA
Name (translations)
Email
info@dcvalliance.nl
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URL
  1. https://www.dcvalliance.nl/
Publisher
Publisher 1
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Naam
Dutch Cardiovascular Alliance (DCVA)
Name (translations)
Email
info@dcvalliance.nl
URL
https://www.dcvalliance.nl/
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Publisher note
Publisher type
Identifier
DCVA
Creator
Creator 1
URI
Naam
Dutch Cardiovascular Alliance (DCVA)
Name (translations)
Email
info@dcvalliance.nl
URL
https://www.dcvalliance.nl/
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DCVA
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Release date 2019-01-01T00:00:00+00:00
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    Identifier DCVA-027
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    Temporal coverage 1
    Start
    2019-01-01T00:00:00+00:00
    End
    2022-01-01T00:00:00+00:00
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    Spatial coverage 1
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    http://publications.europa.eu/resource/authority/country/NLD
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    1. http://publications.europa.eu/resource/authority/data-theme/HEAL
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    1. http://id.loc.gov/vocabulary/iso639-1/en
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    1. http://data.europa.eu/eli/reg/2025/327/oj
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    collection type: Other | disease: Atherosclerosis | data categories: Biological samples | materials: cDNA / mRNA,Cell lines,DNA,RNA,Tissue, cryo preserved,Other | omics: Not available | imaging: N | sex: Not available
    Retention period
    Health data access body
    Qualified relation
    Provenance activity
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    Attribution 1
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    Agent 1
    URI
    Naam
    Dutch Cardiovascular Alliance (DCVA)
    Name (translations)
    Email
    info@dcvalliance.nl
    URL
    https://www.dcvalliance.nl/
    Homepage
    Type
    Identifier
    DCVA
    Rol
    Quality annotations
    URI https://fdp.heart-institute.nl/dataset/a3595869-4a11-40de-837e-460aef74bdbf