Single-cell dissection of the immune response after a myocardial infarction

The immune response plays a pivotal role in initiating cardiac repair and remodeling in both the acute and chronic phase after ST-Elevated myocardial infarction (STEMI). To dissect the longitudinal character of the immune response in STEMI patients over time, we performed single-cell RNA-sequencing (scRNA-seq) on a total of 95,995 peripheral blood mononuclear cells (PBMCs) collected from 38 STEMI patients at hospital admission, 24 hours (acute phase) and 6-8 weeks (chronic phase) after STEMI. Additionally, comparison to healthy controls was performed using previously generated scRNA-seq data on 33,878 PBMCs from 38 age- and sex-matched healthy controls from the Dutch population cohort Lifelines DEEP.

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Title Single-cell dissection of the immune response after a myocardial infarction
Description

The immune response plays a pivotal role in initiating cardiac repair and remodeling in both the acute and chronic phase after ST-Elevated myocardial infarction (STEMI). To dissect the longitudinal character of the immune response in STEMI patients over time, we performed single-cell RNA-sequencing (scRNA-seq) on a total of 95,995 peripheral blood mononuclear cells (PBMCs) collected from 38 STEMI patients at hospital admission, 24 hours (acute phase) and 6-8 weeks (chronic phase) after STEMI. Additionally, comparison to healthy controls was performed using previously generated scRNA-seq data on 33,878 PBMCs from 38 age- and sex-matched healthy controls from the Dutch population cohort Lifelines DEEP.
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http://umcgresearchdatacatalogue.nl/catalogue_rdf/api/rdf/Contacts/firstName=Monique%20van%20der&lastName=Wijst&resource=EGAS00001007021
Name
Monique van der Wijst
Name (translations)
Email
m.g.p.van.der.wijst@umcg.nl
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URL
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Publisher 1
URI
http://umcgresearchdatacatalogue.nl/catalogue_rdf/api/rdf/Agents/id=UMCG&resource=EGAS00001007021
Name
University Medical Center Groningen
Name (translations)
Email
researchdatacatalogue@umcg.nl
URL
https://www.umcg.nl/
Type
Identifier
https://ror.org/03cv38k47
Creator
Creator 1
URI
http://umcgresearchdatacatalogue.nl/catalogue_rdf/api/rdf/Agents/id=UMCG&resource=EGAS00001007021
Name
University Medical Center Groningen
Name (translations)
Email
researchdatacatalogue@umcg.nl
URL
https://www.umcg.nl/
Type
Identifier
https://ror.org/03cv38k47
Landing page https://ega-archive.org/studies/EGAS00001007021
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    Identifier https://metadata.ega-archive.org/studies/EGAS00001007021
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    Spatial coverage 1
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    http://publications.europa.eu/resource/authority/country/NLD
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    Access rights http://publications.europa.eu/resource/authority/access-right/NON_PUBLIC
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    1. http://publications.europa.eu/resource/authority/data-theme/HEAL
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    1. http://data.europa.eu/eli/reg/2022/868/oj
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    URI http://umcgresearchdatacatalogue.nl/catalogue_rdf/api/rdf/Resources/id=EGAS00001007021