@prefix adms: <http://www.w3.org/ns/adms#> .
@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dcatap: <http://data.europa.eu/r5r/> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix healthdcatap: <http://healthdataportal.eu/ns/health#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Resources/id=The%20TWIN-study> a dcat:Dataset ;
    dcatap:applicableLegislation <http://data.europa.eu/eli/reg/2022/868/oj> ;
    healthdcatap:numberOfUniqueIndividuals "138"^^xsd:nonNegativeInteger ;
    dct:accessRights <http://publications.europa.eu/resource/authority/access-right/NON_PUBLIC> ;
    dct:creator <http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Agents/id=UMC%20Utrecht&resource=The%20TWIN-study> ;
    dct:description """Inflammatory Bowel Diseases (IBD), i.e. Crohn’s Disease (CD) and Ulcerative
Colitis (UC), are thought to arise in genetically susceptible individuals in the context of
environmental triggers, with a potential dominant role for the interplay between the gut
microbiota, and the mucosal immune system. However, the relative importance and the
exact role of these factors in the pathogenesis of IBD is presently unknown. Interpretation of
published research in this field is often hampered by reverse causation, and data generated
in animal models cannot be directly extrapolated to the human condition. The disease is
probably triggered years before the occurrence of symptoms, but currently patients are only
identified when clinical disease is established. The preclinical phase of IBD might hold the
key to understanding the pathogenesis of IBD and could provide a huge window of
opportunity of halting or even preventing disease development. At this time, data on this
phase of the disease are limited. Identifying and validating biomarkers and
pathophysiological mechanisms is one of the necessary steps toward prediction, prevention
and optimalization of therapy in IBD care. Unaffected twin-siblings of IBD affected individuals
are at increased risk of developing IBD. Therefore, studying IBD-discordant, IBD-concordant
and non-IBD-concordant twins or multiples gives the unique opportunity to 1) define
mechanisms that underlie (the early development of) IBD and 2) identify and validate
markers of (pre)clinical IBD."""@en,
        ""@nl ;
    dct:identifier <https://doi.org/10.71739/1fg4-jf23> ;
    dct:issued "2026-03-06T10:34:55.357287"^^xsd:dateTime ;
    dct:modified "2026-04-13T21:30:32.979910"^^xsd:dateTime ;
    dct:provenance [ a dct:ProvenanceStatement ;
            rdfs:label "Observational study with both a cross-sectional and longitudinal design"@en,
                ""@nl ] ;
    dct:publisher <http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Agents/id=UMC%20Utrecht&resource=The%20TWIN-study> ;
    dct:spatial <http://publications.europa.eu/resource/authority/country/BEL> ;
    dct:title "Twin cohort for the study of (pre)clinical Inflammatory Bowel Disease in the Netherlands: The TWIN-study"@en,
        ""@nl ;
    adms:versionNotes ""@en,
        ""@nl ;
    dcat:contactPoint <http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Sarah%20Luna&lastName=Dijkstra&resource=The%20TWIN-study> ;
    dcat:keyword "Crohn s disease"@en,
        "cohort"@en,
        "concordance"@en,
        "ibd"@en,
        "twin"@en,
        "twins"@en,
        "ulcerative colitis"@en ;
    dcat:landingPage <https://www.umcutrecht.nl/nl/wetenschappelijk-onderzoek/de-twin-studie-onderzoek-met-tweelingen-naar-chronische-ontstekingsziekten-van-de-darm-ibd> ;
    dcat:theme <http://publications.europa.eu/resource/authority/data-theme/HEAL> .

<http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Contacts/firstName=Sarah%20Luna&lastName=Dijkstra&resource=The%20TWIN-study> a vcard:Kind ;
    vcard:fn "Sarah Luna Dijkstra" ;
    vcard:hasEmail <mailto:s.l.dijkstra-6@umcutrecht.nl> .

<http://data.europa.eu/eli/reg/2022/868/oj> a <http://data.europa.eu/eli/ontology#LegalResource> .

<http://publications.europa.eu/resource/authority/access-right/NON_PUBLIC> a dct:RightsStatement .

<http://publications.europa.eu/resource/authority/country/BEL> a dct:Location .

<https://www.umcutrecht.nl/nl/wetenschappelijk-onderzoek/de-twin-studie-onderzoek-met-tweelingen-naar-chronische-ontstekingsziekten-van-de-darm-ibd> a foaf:Document .

<http://catalogue.hdsu.nl/catalogue-rdf/api/rdf/Agents/id=UMC%20Utrecht&resource=The%20TWIN-study> a foaf:Agent ;
    dct:identifier <https://ror.org/0575yy874> ;
    vcard:hasEmail <mailto:info@umcu.nl> ;
    foaf:homepage <https://www.umcutrecht.nl> ;
    foaf:name "University Medical Center Utrecht" .