@prefix adms: <http://www.w3.org/ns/adms#> .
@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix dcatap: <http://data.europa.eu/r5r/> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix foaf: <http://xmlns.com/foaf/0.1/> .
@prefix healthdcatap: <http://healthdataportal.eu/ns/health#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix vcard: <http://www.w3.org/2006/vcard/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://fdp.heart-institute.nl/dataset/a3595869-4a11-40de-837e-460aef74bdbf> a dcat:Dataset ;
    dcatap:applicableLegislation <http://data.europa.eu/eli/reg/2025/327/oj> ;
    healthdcatap:populationCoverage "collection type: Other | disease: Atherosclerosis | data categories: Biological samples | materials: cDNA / mRNA,Cell lines,DNA,RNA,Tissue, cryo preserved,Other | omics: Not available | imaging: N | sex: Not available"@nl ;
    dct:accessRights <http://publications.europa.eu/resource/authority/access-right/RESTRICTED> ;
    dct:creator [ a foaf:Agent ;
            dct:identifier "DCVA" ;
            vcard:hasEmail <mailto:info@dcvalliance.nl> ;
            foaf:homepage <https://www.dcvalliance.nl/> ;
            foaf:name "Dutch Cardiovascular Alliance (DCVA)" ] ;
    dct:description ""@en,
        "High total cholesterol levels are a major cause of disease burden in both the developed and developing world as a risk factor for ischemic heart disease and stroke. Lowering cholesterol has been  one of the most effective strategy to prevent major cardiovascular event. In this study, we will try to develop a new treatment for hypercholesterolemia by permanently removing PCSK9 from hepatocytes by using cell-derived vesicles."@nl ;
    dct:identifier "DCVA-027" ;
    dct:issued "2019-01-01T00:00:00+00:00"^^xsd:dateTime ;
    dct:language <http://id.loc.gov/vocabulary/iso639-1/en> ;
    dct:modified "2026-04-17T10:32:30.302415"^^xsd:dateTime ;
    dct:provenance [ a dct:ProvenanceStatement ;
            rdfs:label ""@en,
                ""@nl ] ;
    dct:publisher [ a foaf:Agent ;
            dct:identifier "DCVA" ;
            vcard:hasEmail <mailto:info@dcvalliance.nl> ;
            foaf:homepage <https://www.dcvalliance.nl/> ;
            foaf:name "Dutch Cardiovascular Alliance (DCVA)" ] ;
    dct:spatial <http://publications.europa.eu/resource/authority/country/NLD> ;
    dct:temporal [ a dct:PeriodOfTime ;
            dcat:endDate "2022-01-01T00:00:00+00:00"^^xsd:dateTime ;
            dcat:startDate "2019-01-01T00:00:00+00:00"^^xsd:dateTime ] ;
    dct:title ""@en,
        "Technology Of Protein delivery through Extracellular Vesicles to target PCSK9"@nl ;
    adms:versionNotes ""@en,
        ""@nl ;
    dcat:contactPoint [ a vcard:Kind ;
            vcard:fn "DCVA" ;
            vcard:hasEmail <mailto:info@dcvalliance.nl> ;
            vcard:hasURL <['https://www.dcvalliance.nl/']> ] ;
    dcat:keyword "Atherosclerosis"@nl,
        "Biological samples"@nl,
        "Cell lines"@nl,
        "DNA"@nl,
        "Not available"@nl,
        "Other"@nl,
        "RNA"@nl,
        "TOP-EVs"@nl,
        "Tissue"@nl,
        "cDNA   mRNA"@nl,
        "cryo preserved"@nl ;
    dcat:qualifiedAttribution [ a dcat:Attribution ;
            dcat:agent [ a foaf:Agent,
                        foaf:Organization ;
                    dct:identifier "DCVA" ;
                    foaf:homepage <https://www.dcvalliance.nl/> ;
                    foaf:mbox <mailto:info@dcvalliance.nl> ;
                    foaf:name "Dutch Cardiovascular Alliance (DCVA)" ] ] ;
    dcat:theme <http://publications.europa.eu/resource/authority/data-theme/HEAL> .

<http://data.europa.eu/eli/reg/2025/327/oj> a <http://data.europa.eu/eli/ontology#LegalResource> .

<http://id.loc.gov/vocabulary/iso639-1/en> a dct:LinguisticSystem .

<http://publications.europa.eu/resource/authority/access-right/RESTRICTED> a dct:RightsStatement .

<http://publications.europa.eu/resource/authority/country/NLD> a dct:Location .